Marcadores genéticos de preeclampsia en mujeres peruanas

José Pacheco-Romero, Oscar Acosta Conchucos, Doris Huerta Canales, Santiago Cabrera Ramos, Marlene Vargas Chávez, Pedro Mascaro Sánchez, Moisés Huamán Guerrero, José Sandoval Paredes, Rudy López Gabriel, Julio Mateus, Enrique Gil Guevara, Enrique Guevara Rios, Nitza Butrica Ferré, Diana Catari Soto, David Bellido Yarlequé, Gina Custodio González, Andrea Naranjo Adonaire

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

Resumen

Background: Preeclampsia is a multiorgan disorder associated with maternal and perinatal morbimortality. In Peru, incidence is 10% and accounts for 22% of maternal deaths. Genome and genetic epidemiological studies have found an association between preeclampsia and genetic polymorphisms. Objective: To determine the association of the vascular endothelial growth factor (VEGF) +936 C/T and +405 G/C, interleukine-6 (IL-6)-174 G/C, IL-1β-511 C/T, Apo A-1-75 G/A, Apo B-100 2488 C/T (Xbal) polymorphisms with preeclampsia in pregnant Peruvian women. Methods: Were included preeclamptic and healthy (control) pregnant women. Maternal blood samples were subjected to DNA extraction, and molecular genetic analysis was conducted using the PCR-RFLP technique and following a specific protocol for each gene. Allele and genotypic frequencies in the cases and controls were compared. Results: No association was found between the VEGF+936C/T and VEGF+405 polymorphisms and preeclampsia. The frequencies of the GG genotypes and the G allele of the-174 G/C polymorphism in the IL6 gene in preeclamptic and controls showed significant differences, with higher frequencies in cases. For the-511 C/T polymorphism of the IL-1β gene, no significant differences were found in the frequencies of TT genotypes compared with CT+CC. The genotypes and alleles of the Apo-A1-75 G/A and Apo-B100 Xbal variants showed no significant differences between cases and controls.

Título traducido de la contribuciónGenetic markers for preeclampsia in peruvian women
Idioma originalEspañol
Número de artículoe2014437
PublicaciónColombia Medica
Volumen52
N.º1
DOI
EstadoPublicada - 2021

Nota bibliográfica

Publisher Copyright:
© 2021 Universidad del Valle.

Palabras clave

  • Angiogenesis Inducing Agents
  • Apolipoprotein A-I
  • Endothelin-1
  • FLT1 protein, human
  • Interleukin-6
  • Leptin
  • Maternal Death
  • Placenta Growth Factor
  • Pre-Eclampsia
  • Pregnant Women
  • Trophoblasts
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factor Receptor-1

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