TY - JOUR
T1 - Health-Related Quality of Life in Adults with Adolescent- and Adult-onset Systemic Lupus Erythematosus
T2 - A Longitudinal Study of a Multiethnic US Cohort (LUMINA LXXXIV)
AU - Borgia, R. Ezequiel
AU - Ugarte-Gil, Manuel F.
AU - Vilá, Luis M.
AU - Reveille, John D.
AU - McGwin, Gerald
AU - Alarcón, Graciela S.
N1 - Publisher Copyright:
This article is protected by copyright. All rights reserved.
PY - 2022
Y1 - 2022
N2 - Background/Purpose: The long-term impact of childhood-onset systemic lupus erythematosus on Health-related Quality of Life (HRQoL) in adult SLE patients in comparison to those with adult-onset SLE is unknown. We aim to examine and compare HRQoL trajectories in adults with adolescent- and adult-onset SLE. Methods: Patients enrolled in the LUMINA cohort were included. Adolescent-onset SLE were those diagnosed <24 years of age, and adult-onset SLE otherwise. Sociodemographic, clinical, medications, behavioral/psychological and functioning data were obtained. Longitudinal trajectories of the physical component (PCS) and the mental component (MCS) SF-36 summary scores were compared between the groups using a linear mixed model accounting for time-dependent and independent covariates. Results: 470 SLE patients were included (95 adolescent-onset SLE and 375 adult-onset SLE). The mean age at diagnosis was 19.7 years (SD: 2.8) in the adolescent group and 39.3 years (SD: 11.0) in the adult group. Baseline PCS was higher (better physical functioning) in adolescent- when compared to adult-onset SLE (38.9 vs 34.3 respectively, p<0.001); however, the baseline MCS scores was comparable between the groups (41.4 vs 40.5 respectively, p=0.53). The HRQoL improved equally in both groups with no statistically significant difference within and between the groups (last PCS and MCS mean scores: 43.9 and 45.3 in adolescent-onset SLE; 38.1 and 43 in adult-onset SLE respectively). Conclusions: Adults with adolescent-onset SLE exhibited better physical functioning when compared with the adult SLE group despite more severe disease; noteworthy, HRQoL was below the general US population despite clinically meaningful improvement in HRQoL over time in both groups. This article is protected by copyright. All rights reserved.
AB - Background/Purpose: The long-term impact of childhood-onset systemic lupus erythematosus on Health-related Quality of Life (HRQoL) in adult SLE patients in comparison to those with adult-onset SLE is unknown. We aim to examine and compare HRQoL trajectories in adults with adolescent- and adult-onset SLE. Methods: Patients enrolled in the LUMINA cohort were included. Adolescent-onset SLE were those diagnosed <24 years of age, and adult-onset SLE otherwise. Sociodemographic, clinical, medications, behavioral/psychological and functioning data were obtained. Longitudinal trajectories of the physical component (PCS) and the mental component (MCS) SF-36 summary scores were compared between the groups using a linear mixed model accounting for time-dependent and independent covariates. Results: 470 SLE patients were included (95 adolescent-onset SLE and 375 adult-onset SLE). The mean age at diagnosis was 19.7 years (SD: 2.8) in the adolescent group and 39.3 years (SD: 11.0) in the adult group. Baseline PCS was higher (better physical functioning) in adolescent- when compared to adult-onset SLE (38.9 vs 34.3 respectively, p<0.001); however, the baseline MCS scores was comparable between the groups (41.4 vs 40.5 respectively, p=0.53). The HRQoL improved equally in both groups with no statistically significant difference within and between the groups (last PCS and MCS mean scores: 43.9 and 45.3 in adolescent-onset SLE; 38.1 and 43 in adult-onset SLE respectively). Conclusions: Adults with adolescent-onset SLE exhibited better physical functioning when compared with the adult SLE group despite more severe disease; noteworthy, HRQoL was below the general US population despite clinically meaningful improvement in HRQoL over time in both groups. This article is protected by copyright. All rights reserved.
UR - http://www.scopus.com/inward/record.url?scp=85143205351&partnerID=8YFLogxK
U2 - 10.1002/acr.25006
DO - 10.1002/acr.25006
M3 - Artículo
C2 - 36039942
AN - SCOPUS:85143205351
SN - 2151-464X
JO - Arthritis Care and Research
JF - Arthritis Care and Research
ER -