Resumen
Forty-nine subjects received two doses of oral cholera vaccine consisting of whole cells plus recombinant B subunit; this was followed by a booster dose one year later. After the primary series, a significant (greater than twofold) increase in the levels of vibriocidal, anti-cholera toxin immunoglobulin G and anti-cholera toxin immunoglobulin A antibodies occurred in 54, 88, and 81% of the subjects, respectively. Within one year, titers decreased to levels close to baseline. A booster dose then induced rises similar to those which occurred after the initial vaccination. The results suggest that 1-year booster doses may be necessary to maintain immunity against cholera in Latin America.
Idioma original | Inglés |
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Páginas (desde-hasta) | 3726-3728 |
Número de páginas | 3 |
Publicación | Infection and Immunity |
Volumen | 63 |
N.º | 9 |
DOI | |
Estado | Publicada - 1995 |