Isolation of cytotoxic metabolites from targeted peruvian amazonian medicinal plants

José C. Aponte; Abraham J. Vaisberg; Rosario Rojas; Luz Caviedes; Walter H. Lewis; Gerardo Lamas; César Sarasara; Robert H. Gilman; Gerald B. Hammond

doi:10.1021/np070560c

Isolation of cytotoxic metabolites from targeted peruvian amazonian medicinal plants

José C. Aponte, Abraham J. Vaisberg, Rosario Rojas, Luz Caviedes, Walter H. Lewis, Gerardo Lamas, César Sarasara, Robert H. Gilman, Gerald B. Hammond

Museo de Historia Natural

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

28 Citas (Scopus)

Resumen

The antiproliferative bioassay-guided fractionation of five Peruvian plants, Doliocarpus dentatus, Picramnia sellowii, Strychnos mitscherlichii, Iryanthera juruensis, and Croton alnifolius, led to the isolation and identification of their different major cytotoxic constituents, betulinic acid (1), nataloe-emodin (2), bisnordihydrotoxyferine (4), 2′,4′- dihydroxy-6′-methoxy-3,4-methylenedioxydihydrochalcone (5), and 2′,4′-dihydroxy-4,6′-dimethoxydihydrochalcone (6) and 12-O-tetradecanoylphorbol-13-acetate (7), respectively. Eight human tumor cell lines and two nontumorigenic cell lines were used in this investigation. Their in vitro activity against Mycobacterium tuberculosis is also reported.

Idioma original	Inglés estadounidense
Páginas (desde-hasta)	102-105
Número de páginas	4
Publicación	Journal of Natural Products
Volumen	71
N.º	1
DOI	https://doi.org/10.1021/np070560c
Estado	Publicada - 1 ene. 2008

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title = "Isolation of cytotoxic metabolites from targeted peruvian amazonian medicinal plants",

abstract = "The antiproliferative bioassay-guided fractionation of five Peruvian plants, Doliocarpus dentatus, Picramnia sellowii, Strychnos mitscherlichii, Iryanthera juruensis, and Croton alnifolius, led to the isolation and identification of their different major cytotoxic constituents, betulinic acid (1), nataloe-emodin (2), bisnordihydrotoxyferine (4), 2′,4′- dihydroxy-6′-methoxy-3,4-methylenedioxydihydrochalcone (5), and 2′,4′-dihydroxy-4,6′-dimethoxydihydrochalcone (6) and 12-O-tetradecanoylphorbol-13-acetate (7), respectively. Eight human tumor cell lines and two nontumorigenic cell lines were used in this investigation. Their in vitro activity against Mycobacterium tuberculosis is also reported.",

author = "Aponte, {Jos{\'e} C.} and Vaisberg, {Abraham J.} and Rosario Rojas and Luz Caviedes and Lewis, {Walter H.} and Gerardo Lamas and C{\'e}sar Sarasara and Gilman, {Robert H.} and Hammond, {Gerald B.}",

year = "2008",

month = jan,

day = "1",

doi = "10.1021/np070560c",

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journal = "Journal of Natural Products",

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publisher = "American Chemical Society",

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T1 - Isolation of cytotoxic metabolites from targeted peruvian amazonian medicinal plants

AU - Aponte, José C.

AU - Vaisberg, Abraham J.

AU - Rojas, Rosario

AU - Caviedes, Luz

AU - Lewis, Walter H.

AU - Lamas, Gerardo

AU - Sarasara, César

AU - Gilman, Robert H.

AU - Hammond, Gerald B.

PY - 2008/1/1

Y1 - 2008/1/1

N2 - The antiproliferative bioassay-guided fractionation of five Peruvian plants, Doliocarpus dentatus, Picramnia sellowii, Strychnos mitscherlichii, Iryanthera juruensis, and Croton alnifolius, led to the isolation and identification of their different major cytotoxic constituents, betulinic acid (1), nataloe-emodin (2), bisnordihydrotoxyferine (4), 2′,4′- dihydroxy-6′-methoxy-3,4-methylenedioxydihydrochalcone (5), and 2′,4′-dihydroxy-4,6′-dimethoxydihydrochalcone (6) and 12-O-tetradecanoylphorbol-13-acetate (7), respectively. Eight human tumor cell lines and two nontumorigenic cell lines were used in this investigation. Their in vitro activity against Mycobacterium tuberculosis is also reported.

AB - The antiproliferative bioassay-guided fractionation of five Peruvian plants, Doliocarpus dentatus, Picramnia sellowii, Strychnos mitscherlichii, Iryanthera juruensis, and Croton alnifolius, led to the isolation and identification of their different major cytotoxic constituents, betulinic acid (1), nataloe-emodin (2), bisnordihydrotoxyferine (4), 2′,4′- dihydroxy-6′-methoxy-3,4-methylenedioxydihydrochalcone (5), and 2′,4′-dihydroxy-4,6′-dimethoxydihydrochalcone (6) and 12-O-tetradecanoylphorbol-13-acetate (7), respectively. Eight human tumor cell lines and two nontumorigenic cell lines were used in this investigation. Their in vitro activity against Mycobacterium tuberculosis is also reported.

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Isolation of cytotoxic metabolites from targeted peruvian amazonian medicinal plants

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