Actividad leishmanicida de los extractos metanólicos de cuatro ecotipos de Lepidium peruvianum, Chacón (Brassicaceae)

Libertad Alzamora, Hilda Solís, Marisol Rojas, Marisela Calderón, Narda Fajardo, Jenny Quispe, Evelyn Alvarez, Erasmo Honorio Colona Vallejos, Dina Torres

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

1 Cita (Scopus)

Resumen

The classic treatment of the cutaneous leishmaniosis consists on the injection of 15-20 ampoule of Glucantine what causes serious secondary effects. This fact justifies the search of new medications what motivated the present investigation. The objective was to evaluate the leishmanicidal activity of the methanolic extracts (ME) of the white, red, purple and black ecotypes of Lepidium peruvianum Chacon (at present Lepidium meyenii Walp.) about the growth of Leishmania braziliensis peruviana in vitro. The promastigotes reached the logarithmic phase to the fifth day of cultivation at 27°C in the two-phase Columbia medium with 15% of defibrinated sheep blood and they faced, for separate, with the ME to concentrations of 50, 100, 200 and 400 μg/ml. The recounts were made daily with camera Neubauer. The maximum decrease of promastigotes (17.41% of viability) took place to the second day for the purple ecotype with the concentration of 400 μg/ml. The leishmanicidal effect would be related with the imidazolic alkaloids, glucosinolates, flavonoids, tannins and saponines present in the ME. The conclusion is that only ME of the white and purple ecotypes presents leishmanicidal activity, at second day of culture.

Título traducido de la contribuciónLeishmanicidal activity of methanolic extract from four ecotypes of Lepidium peruvianum, Chacón (Brassicaceae)
Idioma originalEspañol
Páginas (desde-hasta)211-214
Número de páginas4
PublicaciónRevista Peruana de Biologia
Volumen13
N.º3
EstadoPublicada - jul 2007
Publicado de forma externa

Palabras clave

  • Ecotype of Maca
  • Leishmania braziliensis peruviana
  • Leishmanicidal activity
  • Lepidium meyenii
  • Lepidium peruvianum
  • Methanolic extract
  • Peruvian medicinal plants

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