TY - JOUR
T1 - Lipid/particle assemblies based on maltodextrin-gum arabic core as bio-carriers
AU - Gomes, Joana F.P.S.
AU - Rocha, Sandra
AU - Pereira, Maria do Carmo
AU - Peres, Ivone
AU - Moreno, Susana
AU - Toca-Herrera, José
AU - Coelho, Manuel A.N.
N1 - Funding Information:
The authors thank David Gil Carton from CIC bioGUNE (Bilbao, Spain) for cryo-TEM measurements. Financial support was provided by the QREN project 1570 – BioCaps and FCT research project PTDC/BIO/69359/2006 and the integrate action AAII-HP2008-081.
PY - 2010/4/1
Y1 - 2010/4/1
N2 - A novel system to carry and protect epigallocatechin gallate (EGCG), an antioxidant from the green tea, is reported. The system consists of maltodextrin and gum arabic nanoparticles coated with egg-yolk l-α-phosphatidylcholine (Egg-PC)/stearylamine (SA) bilayers. In this study, the polysaccharide core was produced by homogenization followed by spray-drying. The lipid coating was performed by the lipid film hydration method. The polysaccharide core revealed negative zeta potential, which changed to opposite signs after lipid coating. The presence of lipid layers was evidenced by cryogenic-transmission (cryo-TEM) and scanning (cryo-SEM) electron microscopy studies. An increase in size was observed after lipid coating as determined by dynamic light scattering (DLS). Atomic force microscopy (AFM) demonstrated that the polysaccharide core provides high resistance to mechanical strength. The lipid/particle assemblies show high retention efficiency of EGCG at physiological pH, opening the possibility of their use for delivery and controlled release of tea catechins.
AB - A novel system to carry and protect epigallocatechin gallate (EGCG), an antioxidant from the green tea, is reported. The system consists of maltodextrin and gum arabic nanoparticles coated with egg-yolk l-α-phosphatidylcholine (Egg-PC)/stearylamine (SA) bilayers. In this study, the polysaccharide core was produced by homogenization followed by spray-drying. The lipid coating was performed by the lipid film hydration method. The polysaccharide core revealed negative zeta potential, which changed to opposite signs after lipid coating. The presence of lipid layers was evidenced by cryogenic-transmission (cryo-TEM) and scanning (cryo-SEM) electron microscopy studies. An increase in size was observed after lipid coating as determined by dynamic light scattering (DLS). Atomic force microscopy (AFM) demonstrated that the polysaccharide core provides high resistance to mechanical strength. The lipid/particle assemblies show high retention efficiency of EGCG at physiological pH, opening the possibility of their use for delivery and controlled release of tea catechins.
KW - Carbohydrate nanoparticles
KW - Catechins
KW - Delivery systems
KW - Lipid coating
UR - http://www.scopus.com/inward/record.url?scp=75949099005&partnerID=8YFLogxK
U2 - 10.1016/j.colsurfb.2009.12.004
DO - 10.1016/j.colsurfb.2009.12.004
M3 - Artículo
C2 - 20060275
AN - SCOPUS:75949099005
SN - 0927-7765
VL - 76
SP - 449
EP - 455
JO - Colloids and Surfaces B: Biointerfaces
JF - Colloids and Surfaces B: Biointerfaces
IS - 2
ER -