Microscopic observation drug susceptibility assay for rapid diagnosis of lymph node tuberculosis and detection of drug resistance

Daniela E. Kirwan; Cesar Ugarte-Gil; Robert H. Gilman; Hasan Rizvi; Eduardo Ticona; Gonzalo Chavez; José Luis Cabrera; Eduardo D. Matos; Carlton A. Evans; David A.J. Moore; Jon S. Friedland

doi:10.1128/JCM.02227-15

Microscopic observation drug susceptibility assay for rapid diagnosis of lymph node tuberculosis and detection of drug resistance

Daniela E. Kirwan, Cesar Ugarte-Gil, Robert H. Gilman, Hasan Rizvi, Eduardo Ticona, Gonzalo Chavez, José Luis Cabrera, Eduardo D. Matos, Carlton A. Evans, David A.J. Moore, Jon S. Friedland

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© 2015, American Society for Microbiology. All Rights Reserved. In this study, 132 patients with lymphadenopathy were investigated. Fifty-two (39.4%) were diagnosed with tuberculosis (TB). The microscopic observation drug susceptibility (MODS) assay provided rapid (13 days), accurate diagnosis (sensitivity, 65.4%) and reliable drug susceptibility testing (DST). Despite its lower sensitivity than that of other methods, its faster results and simultaneous DST are advantageous in resource-poor settings, supporting the incorporation of MODS into diagnostic algorithms for extrapulmonary TB.

Idioma original	Inglés estadounidense
Páginas (desde-hasta)	185-189
Número de páginas	5
Publicación	Journal of Clinical Microbiology
DOI	https://doi.org/10.1128/JCM.02227-15
Estado	Publicada - 1 ene. 2016

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Kirwan, D. E., Ugarte-Gil, C., Gilman, R. H., Rizvi, H., Ticona, E., Chavez, G., Cabrera, J. L., Matos, E. D., Evans, C. A., Moore, D. A. J., & Friedland, J. S. (2016). Microscopic observation drug susceptibility assay for rapid diagnosis of lymph node tuberculosis and detection of drug resistance. Journal of Clinical Microbiology, 185-189. https://doi.org/10.1128/JCM.02227-15

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doi = "10.1128/JCM.02227-15",

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AU - Kirwan, Daniela E.

AU - Ugarte-Gil, Cesar

AU - Gilman, Robert H.

AU - Rizvi, Hasan

AU - Ticona, Eduardo

AU - Chavez, Gonzalo

AU - Cabrera, José Luis

AU - Matos, Eduardo D.

AU - Evans, Carlton A.

AU - Moore, David A.J.

AU - Friedland, Jon S.

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N2 - © 2015, American Society for Microbiology. All Rights Reserved. In this study, 132 patients with lymphadenopathy were investigated. Fifty-two (39.4%) were diagnosed with tuberculosis (TB). The microscopic observation drug susceptibility (MODS) assay provided rapid (13 days), accurate diagnosis (sensitivity, 65.4%) and reliable drug susceptibility testing (DST). Despite its lower sensitivity than that of other methods, its faster results and simultaneous DST are advantageous in resource-poor settings, supporting the incorporation of MODS into diagnostic algorithms for extrapulmonary TB.

AB - © 2015, American Society for Microbiology. All Rights Reserved. In this study, 132 patients with lymphadenopathy were investigated. Fifty-two (39.4%) were diagnosed with tuberculosis (TB). The microscopic observation drug susceptibility (MODS) assay provided rapid (13 days), accurate diagnosis (sensitivity, 65.4%) and reliable drug susceptibility testing (DST). Despite its lower sensitivity than that of other methods, its faster results and simultaneous DST are advantageous in resource-poor settings, supporting the incorporation of MODS into diagnostic algorithms for extrapulmonary TB.

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Microscopic observation drug susceptibility assay for rapid diagnosis of lymph node tuberculosis and detection of drug resistance

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