Molecular investigation into a malaria outbreak in cusco, Peru: Plasmodium falciparum BV1 lineage is linked to a second outbreak in recent times

Sheila Akinyi Okoth, Stella M. Chenet, Nancy Arrospide, Sonia Gutierrez, Cesar Cabezas, Jose Antonio Matta, Venkatachalam Udhayakumar

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

6 Citas (Scopus)

Resumen

In November 2013, a Plasmodium falciparum malaria outbreak of 11 cases occurred in Cusco, southern Peru, where falciparum malaria had not been reported since 1946. Although initial microscopic diagnosis reported only Plasmodium vivax infection in each of the specimens, subsequent examination by the national reference laboratory confirmed P. falciparum infection in all samples. Molecular typing of four available isolates revealed identity as the B-variant (BV1) strain that was responsible for a malaria outbreak in Tumbes, northern Peru, between 2010 and 2012. The P. falciparum BV1 strain is multidrug resistant, can escape detection by PfHRP2-based rapid diagnostic tests, and has contributed to two malaria outbreaks in Peru. This investigation highlights the importance of accurate species diagnosis given the potential for P. falciparum to be reintroduced to regions where it may have been absent. Similar molecular epidemiological investigations can track the probable source(s) of outbreak parasite strains for malaria surveillance and control purposes.

Idioma originalInglés
Páginas (desde-hasta)128-131
Número de páginas4
PublicaciónAmerican Journal of Tropical Medicine and Hygiene
Volumen94
N.º1
DOI
EstadoPublicada - ene 2016

Nota bibliográfica

Publisher Copyright:
© 2016 by The American Society of Tropical Medicine and Hygiene.

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