Alelos mutantes asociados a la resistencia a cloroquina y sulfadoxina-pirimetamina en Plasmodium falciparum de las fronteras Ecuador-Perú y Ecuador-Colombia

Nancy Arrospide Velasco, Gisely Hijar-Guerra, Doménica de Mora, César Eduardo Diaz-Cortéz, Raúl Veloz-Perez, Sonia Gutierrez, Cesar Augusto Cabezas Sanchez

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

2 Citas (Scopus)

Resumen

The frequency of mutations in pfCRT and DHFR/DHPS genes of Plasmodium falciparum associated with resistance to chloroquine and sulfadoxine-pyrimethamine was evaluated in 83 strains from the districts of Esmeralda and Machala, located on the borders of Ecuador-Peru and Ecuador-Colombia in 2002. Polymerase chain reaction (PCR), conventional and its variants, was used. Mutations in the pfCRT gene were found in more than 90% of the samples from Esmeralda and Machala. For the DHFR gene, 90% of the strains were mutant samples from Esmeralda, 3 were double mutations and 1 was a triple mutation. In Machala, 25% were simple mutant forms and 75% mixed mutant forms (wild forms/mutant). In conclusion, resistance to chloroquine has been fixed in strains carrying K76T pfCRT mutation, whereas genetic imprinting for resistance to pyrimethamine is evolving, particularly in the district of Esmeralda.

Título traducido de la contribuciónMutant alleles associated to chloroquine and sulfadoxine-pyrimethanime resistance in Plasmodium falciparum of the Ecuador-Peru and Ecuador-Colombia borders
Idioma originalEspañol
Páginas (desde-hasta)282-287
Número de páginas6
PublicaciónRevista Peruana de Medicina de Experimental y Salud Publica
Volumen31
N.º2
EstadoPublicada - 2014
Publicado de forma externa

Palabras clave

  • Bacterial
  • Chloroquine
  • Drug resistance
  • Plasmodium falciparum
  • Pyrimethamine (source: MeSH NLM)
  • Sulfadoxine

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