Protección osteoarticular de Zea mays l. Variedad morada (maíz morado) en artritis experimental en ratas

Daisy Flores-Cortez, Eduardo Villalobos-Pacheco, Armando Rojo-Mejia, Manuel Palomino-Yamamoto, Yngerman Martin Ramirez

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

1 Cita (Scopus)

Resumen

Objectives. To evaluate the protective effect of Zea mays L., purple variety (purple corn) against inflammatory response and osteoarticular damage in rats with experimental arthritis. Materials and Methods. Sixty-five Holtzman rats were used, assigned to seven groups: G1 (n=5): control; G2 (n=10): pristane (PIA) + distilled water; G3 (n=10): PIA + methotrexate 0.1 mg/kg; G4 (n=10): PIA + indomethacin 0.6 mg/kg; G5 (n=10): PIA + Zea mays 100 mg/kg; G6 (n=10): PIA + Zea mays 1000 mg/kg, and G7 (n=10): PIA + methotrexate 0.1 mg/kg + Zea mays 1000 mg/kg. Treatments were administered by orogastric cannula daily for 21 days; pristane was administered subdermal only on day 1. Volume of hind leg was recorded with a digital plethysmometer. The radiological analysis of the legs was evaluated according to the modified Clark criteria. Results. The percentage of inflammation at the end of the experiment was: (G1) 1.50 ± 0.5; (G2) 13.73 ± 8.4; (G3) 14.76 ± 8.8; (G4) 14.22 ± 9.0; (G5) 10.81 ± 9.1; (G6) 5.31 ± 1.4; (G7) 6.38 ± 0.5. The radiological scores of the affected areas were: (G1) 0.6; (G2) 3.5; (G3) 0.6; (G4) 1.7; (G5) 1.9; (G6) 1.4; (G7) 1.0. Only the groups Zea mays L. 1000 mg/kg and methotrexate + Zea mays L. 1000 mg/kg showed a significantly lower inflammatory response (p<0.05) and showed significantly lower joint scores in relation to PIA. Conclusions. Zea mays L. (purple corn) reduces the inflammatory process and radiological modifications of PIA-induced arthritis in rats in a dose-dependent manner.

Título traducido de la contribuciónOsteoarticular protection of Zea mays l. Purple variety (purple corn) in experimental arthritis in rats
Idioma originalEspañol
Páginas (desde-hasta)441-448
Número de páginas8
PublicaciónRevista Peruana de Medicina de Experimental y Salud Publica
Volumen35
N.º3
DOI
EstadoPublicada - 1 jul 2018

Nota bibliográfica

Publisher Copyright:
© 2018, Instituto Nacional de Salud. All rights reserved.

Palabras clave

  • Medicinal plants
  • Phytotherapy
  • Purple corn
  • Rheumatoid arthritis (source: MeSH NLM)

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