TY - JOUR
T1 - Population genetic analysis of Bartonella bacilliformis isolates from areas of Peru where Carrion's disease is endemic and epidemic
AU - Hambuch, Tina M.
AU - Handley, Scott A.
AU - Ellis, Barbara
AU - Chamberlin, Judith
AU - Romero, Sofia
AU - Regnery, Russell
PY - 2004/8
Y1 - 2004/8
N2 - Carrion's disease is caused by infection with the α-proteobacterium Bartonella bacilliformis. Distribution of the disease is considered coincident with the distribution of its known vector, the sand fly Lutzomyia verrucarum. Recent epidemics of B. bacilliformis infections associated with atypical symptomatology in nonendemic regions have raised questions regarding the historic and present distribution of this bacterium and the scope of disease that infection causes. Phylogenetic relationships and genomic diversity of 18 B. bacilliformis isolates (10 isolates from a region where Carrion's disease is epidemic, Cuzco, Peru, and 8 isolates from a region where Carrion's disease is endemic, Caraz, Peru) were assessed using genomic data generated by infrequent restriction site PCR and gene sequence analysis of the flagellin gltA and ialB genes. A population genetic analysis of the genomic diversity suggests that what was once considered an epidemic region of Peru did not result from the recent introduction of B. bacilliformis.
AB - Carrion's disease is caused by infection with the α-proteobacterium Bartonella bacilliformis. Distribution of the disease is considered coincident with the distribution of its known vector, the sand fly Lutzomyia verrucarum. Recent epidemics of B. bacilliformis infections associated with atypical symptomatology in nonendemic regions have raised questions regarding the historic and present distribution of this bacterium and the scope of disease that infection causes. Phylogenetic relationships and genomic diversity of 18 B. bacilliformis isolates (10 isolates from a region where Carrion's disease is epidemic, Cuzco, Peru, and 8 isolates from a region where Carrion's disease is endemic, Caraz, Peru) were assessed using genomic data generated by infrequent restriction site PCR and gene sequence analysis of the flagellin gltA and ialB genes. A population genetic analysis of the genomic diversity suggests that what was once considered an epidemic region of Peru did not result from the recent introduction of B. bacilliformis.
UR - http://www.scopus.com/inward/record.url?scp=3843068853&partnerID=8YFLogxK
U2 - 10.1128/JCM.42.8.3675-3680.2004
DO - 10.1128/JCM.42.8.3675-3680.2004
M3 - Artículo
C2 - 15297516
AN - SCOPUS:3843068853
SN - 0095-1137
VL - 42
SP - 3675
EP - 3680
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
IS - 8
ER -