TY - JOUR
T1 - Preclinical testing of Peruvian anti-bothropic anti-venom against Bothrops andianus snake venom
AU - Schneider, Francisco S.
AU - Starling, Maria C.
AU - Duarte, Clara G.
AU - Machado de Avila, Ricardo
AU - Kalapothakis, Evanguedes
AU - Silva Suarez, Walter
AU - Tintaya, Benigno
AU - Flores Garrido, Karin
AU - Seraylan Ormachea, Silvia
AU - Yarleque, Armando
AU - Bonilla, César
AU - Chávez-Olórtegui, Carlos
N1 - Funding Information:
This research was supported by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brazil – CAPES (TOXINOLOGIA No 23038000825/2011-63 ), Fundação de Amparo a Pesquisa do Estado de Minas Gerais, Brazil (FAPEMIG) and by funds of the INCTTOX PROGRAM of Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil (CNPq). The authors gratefully acknowledge the financial support and assistance of the Instituto Nacional de Salud (Lima, Peru) without which it would not have been possible to carry out this study. We would like to express our gratitude to Dr. Michael Richardson and Jessica McCormack for revising this manuscript.
PY - 2012/11
Y1 - 2012/11
N2 - Bothrops andianus is a venomous snake found in the area of Machu Picchu (Peru). Its venom is not included in the antigenic pool used for production of the Peruvian anti-bothropic anti-venom. B. andianus venom can elicit many biological effects such as hemorrhage, hemolysis, proteolytic activity and lethality. The Peruvian anti-bothropic anti-venom displays consistent cross-reactivity with B. andianus venom, by ELISA and Western Blotting and is also effective in neutralizing the venom's toxic activities.
AB - Bothrops andianus is a venomous snake found in the area of Machu Picchu (Peru). Its venom is not included in the antigenic pool used for production of the Peruvian anti-bothropic anti-venom. B. andianus venom can elicit many biological effects such as hemorrhage, hemolysis, proteolytic activity and lethality. The Peruvian anti-bothropic anti-venom displays consistent cross-reactivity with B. andianus venom, by ELISA and Western Blotting and is also effective in neutralizing the venom's toxic activities.
KW - Andean snake
KW - Anti-venom
KW - Bothrops andianus
KW - Toxicity
KW - Venom
UR - http://www.scopus.com/inward/record.url?scp=84864810767&partnerID=8YFLogxK
U2 - 10.1016/j.toxicon.2012.06.018
DO - 10.1016/j.toxicon.2012.06.018
M3 - Artículo
C2 - 22796381
AN - SCOPUS:84864810767
SN - 0041-0101
VL - 60
SP - 1018
EP - 1021
JO - Toxicon
JF - Toxicon
IS - 6
ER -