Preclinical testing of three south American antivenoms against the venoms of five medically-important Peruvian snake venoms

G. D. Laing; A. Yarleque; A. Marcelo; E. Rodriguez; D. A. Warrell; R. D.G. Theakston

doi:10.1016/j.toxicon.2004.03.020

Preclinical testing of three south American antivenoms against the venoms of five medically-important Peruvian snake venoms

G. D. Laing, A. Yarleque, A. Marcelo, E. Rodriguez, D. A. Warrell, R. D.G. Theakston

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Resumen

World Health Organization (WHO)-recommended preclinical in vivo and in vitro studies were carried out to compare the efficacy of Brazilian, Peruvian and Colombian antivenoms in neutralizing the venom toxins responsible for the lethal, haemorrhagic, necrotizing, coagulant and defibrinogenating effects of five medically-important Peruvian snake venoms. Overall, the Brazilian antivenom was found to be the most effective followed by the Peruvian and Colombian antivenoms. However, it was concluded that all three antivenoms would be acceptable for use in a randomised clinical trial in envenomed humans in Peru.

Idioma original	Inglés
Páginas (desde-hasta)	103-106
Número de páginas	4
Publicación	Toxicon
Volumen	44
N.º	1
DOI	https://doi.org/10.1016/j.toxicon.2004.03.020
Estado	Publicada - jul. 2004

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title = "Preclinical testing of three south American antivenoms against the venoms of five medically-important Peruvian snake venoms",

abstract = "World Health Organization (WHO)-recommended preclinical in vivo and in vitro studies were carried out to compare the efficacy of Brazilian, Peruvian and Colombian antivenoms in neutralizing the venom toxins responsible for the lethal, haemorrhagic, necrotizing, coagulant and defibrinogenating effects of five medically-important Peruvian snake venoms. Overall, the Brazilian antivenom was found to be the most effective followed by the Peruvian and Colombian antivenoms. However, it was concluded that all three antivenoms would be acceptable for use in a randomised clinical trial in envenomed humans in Peru.",

keywords = "In vitro tests, In vivo tests, Peru, South American antivenoms, World Health Organization",

author = "Laing, {G. D.} and A. Yarleque and A. Marcelo and E. Rodriguez and Warrell, {D. A.} and Theakston, {R. D.G.}",

note = "Funding Information: The authors gratefully acknowledge the financial support, advice and assistance of the British Council (Lima) without which it would not have been possible to carry out this study.",

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T1 - Preclinical testing of three south American antivenoms against the venoms of five medically-important Peruvian snake venoms

AU - Laing, G. D.

AU - Yarleque, A.

AU - Marcelo, A.

AU - Rodriguez, E.

AU - Warrell, D. A.

AU - Theakston, R. D.G.

N1 - Funding Information: The authors gratefully acknowledge the financial support, advice and assistance of the British Council (Lima) without which it would not have been possible to carry out this study.

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N2 - World Health Organization (WHO)-recommended preclinical in vivo and in vitro studies were carried out to compare the efficacy of Brazilian, Peruvian and Colombian antivenoms in neutralizing the venom toxins responsible for the lethal, haemorrhagic, necrotizing, coagulant and defibrinogenating effects of five medically-important Peruvian snake venoms. Overall, the Brazilian antivenom was found to be the most effective followed by the Peruvian and Colombian antivenoms. However, it was concluded that all three antivenoms would be acceptable for use in a randomised clinical trial in envenomed humans in Peru.

AB - World Health Organization (WHO)-recommended preclinical in vivo and in vitro studies were carried out to compare the efficacy of Brazilian, Peruvian and Colombian antivenoms in neutralizing the venom toxins responsible for the lethal, haemorrhagic, necrotizing, coagulant and defibrinogenating effects of five medically-important Peruvian snake venoms. Overall, the Brazilian antivenom was found to be the most effective followed by the Peruvian and Colombian antivenoms. However, it was concluded that all three antivenoms would be acceptable for use in a randomised clinical trial in envenomed humans in Peru.

KW - In vitro tests

KW - In vivo tests

KW - Peru

KW - South American antivenoms

KW - World Health Organization

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U2 - 10.1016/j.toxicon.2004.03.020

DO - 10.1016/j.toxicon.2004.03.020

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SN - 0041-0101

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JO - Toxicon

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Preclinical testing of three south American antivenoms against the venoms of five medically-important Peruvian snake venoms

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