Protection against Oxidative Stress and Metabolic Alterations by Synthetic Peptides Derived from Erythrina edulis Seed Protein

Nathaly Rodríguez-Arana, Karim Jiménez-Aliaga, Arturo Intiquilla, José A. León, Eduardo Flores, Amparo Iris Zavaleta, Víctor Izaguirre, Christian Solis-Calero, Blanca Hernández-Ledesma

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

Resumen

The ability of multifunctional food-derived peptides to act on different body targets make them promising alternatives in the prevention/management of chronic disorders. The potential of Erythrina edulis (pajuro) protein as a source of multifunctional peptides was proven. Fourteen selected synthetic peptides identified in an alcalase hydrolyzate from pajuro protein showed in vitro antioxidant, anti-hypertensive, anti-diabetic, and/or anti-obesity effects. The radical scavenging properties of the peptides could be responsible for the potent protective effects observed against the oxidative damage caused by FeSO4 in neuroblastoma cells. Moreover, their affinity towards the binding cavity of angiotensin-converting enzyme (ACE) and dipeptidyl peptidase IV (DPP-IV) were predicted by molecular modeling. The results demonstrated that some peptides such as YPSY exhibited promising binding at both enzymes, supporting the role of pajuro protein as a novel ingredient of functional foods or nutraceuticals for prevention/management of oxidative stress, hypertension, and metabolic-alteration-associated chronic diseases.

Idioma originalInglés
Número de artículo2101
PublicaciónAntioxidants
Volumen11
N.º11
DOI
EstadoPublicada - nov. 2022

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