Síntesis de acil-hidrazona a partir del ácido úsnico e isoniazida y su actividad anti-Mycobacterium tuberculosis

Melissa Barrera Tomas; Gloria Eva Tomas Chota; Patricia Sheen Cortavarría; Patricia Fuentes Bonilla; Miguel Angel Inocente Camones; Julio Santiago Contreras

doi:10.15446/rev.colomb.quim.v46n3.61980

Síntesis de acil-hidrazona a partir del ácido úsnico e isoniazida y su actividad anti-Mycobacterium tuberculosis

Melissa Barrera Tomas, Gloria Eva Tomas Chota, Patricia Sheen Cortavarría, Patricia Fuentes Bonilla, Miguel Angel Inocente Camones, Julio Santiago Contreras

Resultado de la investigación: Contribución a una revista › Artículo › revisión exhaustiva

5 Citas (Scopus)

Resumen

Compound usnic acid (1), isolated from lichen Evernia prunastri (Cajamarca-Peru) and the synthesis and characterization of its acyl-hydrazone (2), from the condensation reaction between usnic acid and isoniazid in an ethanol solution under reflux, giving an overall yield of 95%, were evaluated. Both compounds were evaluated and compared with isoniazid according to its antiMycobacterium tuberculosis activity based on the tetrazolium microplate assay (TEMA). Compound 1 had MIC (minimal inhibitory concentration) value of 16.0 μg/mL in each test of H37Rv (susceptible type), TB DM 97 (resistant wild type) and MDR DM 1098 (multi drug resistances type) strains. In similar tests, compound 2 MIC values were 2.0, 64.0 and 64.0 μg/mL respectively.

Título traducido de la contribución	Synthesis of acyl-hydrazone from usnic acid and isoniazid and its anti-Mycobacterium tuberculosis activity
Idioma original	Español
Páginas (desde-hasta)	17-21
Número de páginas	5
Publicación	Revista Colombiana de Quimica
Volumen	46
N.º	3
DOI	https://doi.org/10.15446/rev.colomb.quim.v46n3.61980
Estado	Publicada - 2017

Nota bibliográfica

Publisher Copyright:
© 2017, Universidad Nacional de Colombia, Inc. All rights reserved.

Palabras clave

Condensation reaction
Evernia prunastri
MIC
TEMA

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10.15446/rev.colomb.quim.v46n3.61980

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title = "S{\'i}ntesis de acil-hidrazona a partir del {\'a}cido {\'u}snico e isoniazida y su actividad anti-Mycobacterium tuberculosis",

abstract = "Compound usnic acid (1), isolated from lichen Evernia prunastri (Cajamarca-Peru) and the synthesis and characterization of its acyl-hydrazone (2), from the condensation reaction between usnic acid and isoniazid in an ethanol solution under reflux, giving an overall yield of 95%, were evaluated. Both compounds were evaluated and compared with isoniazid according to its antiMycobacterium tuberculosis activity based on the tetrazolium microplate assay (TEMA). Compound 1 had MIC (minimal inhibitory concentration) value of 16.0 μg/mL in each test of H37Rv (susceptible type), TB DM 97 (resistant wild type) and MDR DM 1098 (multi drug resistances type) strains. In similar tests, compound 2 MIC values were 2.0, 64.0 and 64.0 μg/mL respectively.",

keywords = "Condensation reaction, Evernia prunastri, MIC, TEMA",

author = "{Barrera Tomas}, Melissa and {Tomas Chota}, {Gloria Eva} and {Sheen Cortavarr{\'i}a}, Patricia and {Fuentes Bonilla}, Patricia and {Inocente Camones}, {Miguel Angel} and {Santiago Contreras}, Julio",

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doi = "10.15446/rev.colomb.quim.v46n3.61980",

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AU - Barrera Tomas, Melissa

AU - Tomas Chota, Gloria Eva

AU - Sheen Cortavarría, Patricia

AU - Fuentes Bonilla, Patricia

AU - Inocente Camones, Miguel Angel

AU - Santiago Contreras, Julio

PY - 2017

Y1 - 2017

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AB - Compound usnic acid (1), isolated from lichen Evernia prunastri (Cajamarca-Peru) and the synthesis and characterization of its acyl-hydrazone (2), from the condensation reaction between usnic acid and isoniazid in an ethanol solution under reflux, giving an overall yield of 95%, were evaluated. Both compounds were evaluated and compared with isoniazid according to its antiMycobacterium tuberculosis activity based on the tetrazolium microplate assay (TEMA). Compound 1 had MIC (minimal inhibitory concentration) value of 16.0 μg/mL in each test of H37Rv (susceptible type), TB DM 97 (resistant wild type) and MDR DM 1098 (multi drug resistances type) strains. In similar tests, compound 2 MIC values were 2.0, 64.0 and 64.0 μg/mL respectively.

KW - Condensation reaction

KW - Evernia prunastri

KW - MIC

KW - TEMA

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AN - SCOPUS:85029348693

SN - 0120-2804

VL - 46

SP - 17

EP - 21

JO - Revista Colombiana de Quimica

JF - Revista Colombiana de Quimica

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ER -

Síntesis de acil-hidrazona a partir del ácido úsnico e isoniazida y su actividad anti-Mycobacterium tuberculosis

Resumen

Nota bibliográfica

Palabras clave

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Huella

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