TY - JOUR
T1 - Screening of medicinal plants traditionally used in Peruvian Amazon for in vitro antioxidant and anticancer potential
AU - Tauchen, Jan
AU - Huml, Lukas
AU - Bortl, Ludvik
AU - Doskocil, Ivo
AU - Jarosova, Veronika
AU - Marsik, Petr
AU - Frankova, Adela
AU - Clavo Peralta, Zoyla Mirella
AU - Chuspe Zans, Maria Elena
AU - Havlik, Jaroslav
AU - Lapcik, Oldrich
AU - Kokoska, Ladislav
PY - 2019/9/17
Y1 - 2019/9/17
N2 - © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. Plants mentioned in this study have numerous records in traditional Peruvian medicine being used in treatment of cancer and other diseases likely to be associated with oxidative stress. Amongst the eight plant species tested, only Dysphania ambrosioides exhibited combinatory antioxidant and anti-proliferative effect on a broad spectrum of cancer cells (DPPH and ORAC values = 80.6 and 687.3 μg TE/mg extract, respectively; IC50 against Caco-2, HT-29 and Hep-G2 = 129.2, 69.9 and 130.6, respectively). Alkaloids and phenolic compounds might significantly contribute to anticancer/antioxidant activity of this plant. The results justify the traditional medicinal use of this plant. Our findings further suggest that D. ambrosioides might serve as a prospective material for further development of novel plant-based antioxidant and/or anti-proliferative agents. Detailed analysis of chemical composition together with toxicology assessments and in vivo antioxidant/anti-proliferative activity of this plant should be carried out in order to verify its potential practical use.
AB - © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. Plants mentioned in this study have numerous records in traditional Peruvian medicine being used in treatment of cancer and other diseases likely to be associated with oxidative stress. Amongst the eight plant species tested, only Dysphania ambrosioides exhibited combinatory antioxidant and anti-proliferative effect on a broad spectrum of cancer cells (DPPH and ORAC values = 80.6 and 687.3 μg TE/mg extract, respectively; IC50 against Caco-2, HT-29 and Hep-G2 = 129.2, 69.9 and 130.6, respectively). Alkaloids and phenolic compounds might significantly contribute to anticancer/antioxidant activity of this plant. The results justify the traditional medicinal use of this plant. Our findings further suggest that D. ambrosioides might serve as a prospective material for further development of novel plant-based antioxidant and/or anti-proliferative agents. Detailed analysis of chemical composition together with toxicology assessments and in vivo antioxidant/anti-proliferative activity of this plant should be carried out in order to verify its potential practical use.
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U2 - 10.1080/14786419.2018.1462180
DO - 10.1080/14786419.2018.1462180
M3 - Article
SN - 1478-6419
SP - 2718
EP - 2721
JO - Natural Product Research
JF - Natural Product Research
ER -
