Serum antigen detection in the diagnosis, treatment, and follow-up of neurocysticercosis patients

H. H. Garcia; R. M.E. Parkhouse; R. H. Gilman; T. Montenegro; T. Bernal; S. M. Martinez; A. E. Gonzalez; V. C.W. Tsang; L. J.S. Harrison

doi:10.1016/S0035-9203(00)90228-1

Serum antigen detection in the diagnosis, treatment, and follow-up of neurocysticercosis patients

H. H. Garcia, R. M.E. Parkhouse, R. H. Gilman, T. Montenegro, T. Bernal, S. M. Martinez, A. E. Gonzalez, V. C.W. Tsang, L. J.S. Harrison

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Resumen

The efficacy of albendazole (ABZ) treatment for human neurocysticercosis (NCC) was assessed by using a monoclonal antibody-based parasite antigen detection ELISA which specifically detects the products of living cysticerci in human serum. The assay displayed 85% diagnostic sensitivity, detecting 39 of 46 NCC cases. Only patients with a single viable cyst or only enhancing lesions (degenerating parasites) were seronegative. Specificity of the assay was 92% (23/25) when tested in healthy Peruvian volunteers. In 'cured' patients, in whom all parasites died after ABZ therapy, parasite antigen levels fell sharply by 3 months post treatment. This pattern was not observed in patients refractory to treatment. The sensitivity of the assay with serum samples, and its ability to identify successfully treated patients, make this monoclonal antibody-based ELISA the test of choice for the follow-up of NCC cases.

Idioma original	Inglés estadounidense
Páginas (desde-hasta)	673-676
Número de páginas	4
Publicación	Transactions of the Royal Society of Tropical Medicine and Hygiene
DOI	https://doi.org/10.1016/S0035-9203(00)90228-1
Estado	Publicada - 1 ene. 2000

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Garcia, H. H., Parkhouse, R. M. E., Gilman, R. H., Montenegro, T., Bernal, T., Martinez, S. M., Gonzalez, A. E., Tsang, V. C. W., & Harrison, L. J. S. (2000). Serum antigen detection in the diagnosis, treatment, and follow-up of neurocysticercosis patients. Transactions of the Royal Society of Tropical Medicine and Hygiene, 673-676. https://doi.org/10.1016/S0035-9203(00)90228-1

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title = "Serum antigen detection in the diagnosis, treatment, and follow-up of neurocysticercosis patients",

abstract = "The efficacy of albendazole (ABZ) treatment for human neurocysticercosis (NCC) was assessed by using a monoclonal antibody-based parasite antigen detection ELISA which specifically detects the products of living cysticerci in human serum. The assay displayed 85% diagnostic sensitivity, detecting 39 of 46 NCC cases. Only patients with a single viable cyst or only enhancing lesions (degenerating parasites) were seronegative. Specificity of the assay was 92% (23/25) when tested in healthy Peruvian volunteers. In 'cured' patients, in whom all parasites died after ABZ therapy, parasite antigen levels fell sharply by 3 months post treatment. This pattern was not observed in patients refractory to treatment. The sensitivity of the assay with serum samples, and its ability to identify successfully treated patients, make this monoclonal antibody-based ELISA the test of choice for the follow-up of NCC cases.",

author = "Garcia, {H. H.} and Parkhouse, {R. M.E.} and Gilman, {R. H.} and T. Montenegro and T. Bernal and Martinez, {S. M.} and Gonzalez, {A. E.} and Tsang, {V. C.W.} and Harrison, {L. J.S.}",

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doi = "10.1016/S0035-9203(00)90228-1",

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AU - Garcia, H. H.

AU - Parkhouse, R. M.E.

AU - Gilman, R. H.

AU - Montenegro, T.

AU - Bernal, T.

AU - Martinez, S. M.

AU - Gonzalez, A. E.

AU - Tsang, V. C.W.

AU - Harrison, L. J.S.

PY - 2000/1/1

Y1 - 2000/1/1

N2 - The efficacy of albendazole (ABZ) treatment for human neurocysticercosis (NCC) was assessed by using a monoclonal antibody-based parasite antigen detection ELISA which specifically detects the products of living cysticerci in human serum. The assay displayed 85% diagnostic sensitivity, detecting 39 of 46 NCC cases. Only patients with a single viable cyst or only enhancing lesions (degenerating parasites) were seronegative. Specificity of the assay was 92% (23/25) when tested in healthy Peruvian volunteers. In 'cured' patients, in whom all parasites died after ABZ therapy, parasite antigen levels fell sharply by 3 months post treatment. This pattern was not observed in patients refractory to treatment. The sensitivity of the assay with serum samples, and its ability to identify successfully treated patients, make this monoclonal antibody-based ELISA the test of choice for the follow-up of NCC cases.

AB - The efficacy of albendazole (ABZ) treatment for human neurocysticercosis (NCC) was assessed by using a monoclonal antibody-based parasite antigen detection ELISA which specifically detects the products of living cysticerci in human serum. The assay displayed 85% diagnostic sensitivity, detecting 39 of 46 NCC cases. Only patients with a single viable cyst or only enhancing lesions (degenerating parasites) were seronegative. Specificity of the assay was 92% (23/25) when tested in healthy Peruvian volunteers. In 'cured' patients, in whom all parasites died after ABZ therapy, parasite antigen levels fell sharply by 3 months post treatment. This pattern was not observed in patients refractory to treatment. The sensitivity of the assay with serum samples, and its ability to identify successfully treated patients, make this monoclonal antibody-based ELISA the test of choice for the follow-up of NCC cases.

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JO - Transactions of the Royal Society of Tropical Medicine and Hygiene

JF - Transactions of the Royal Society of Tropical Medicine and Hygiene

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Serum antigen detection in the diagnosis, treatment, and follow-up of neurocysticercosis patients

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