TY - JOUR
T1 - Synthesis of acyl-hydrazone from usnic acid and isoniazid and its anti-Mycobacterium tuberculosis activity
AU - Barrera Tomas, Melissa
AU - Tomas Chota, Gloria Eva
AU - Sheen Cortavarría, Patricia
AU - Fuentes Bonilla, Patricia
AU - Inocente Camones, Miguel Angel
AU - Santiago Contreras, Julio
PY - 2017/1/1
Y1 - 2017/1/1
N2 - © 2017, Universidad Nacional de Colombia, Inc. All rights reserved. Compound usnic acid (1), isolated from lichen Evernia prunastri (Cajamarca-Peru) and the synthesis and characterization of its acyl-hydrazone (2), from the condensation reaction between usnic acid and isoniazid in an ethanol solution under reflux, giving an overall yield of 95%, were evaluated. Both compounds were evaluated and compared with isoniazid according to its antiMycobacterium tuberculosis activity based on the tetrazolium microplate assay (TEMA). Compound 1 had MIC (minimal inhibitory concentration) value of 16.0 μg/mL in each test of H37Rv (susceptible type), TB DM 97 (resistant wild type) and MDR DM 1098 (multi drug resistances type) strains. In similar tests, compound 2 MIC values were 2.0, 64.0 and 64.0 μg/mL respectively.
AB - © 2017, Universidad Nacional de Colombia, Inc. All rights reserved. Compound usnic acid (1), isolated from lichen Evernia prunastri (Cajamarca-Peru) and the synthesis and characterization of its acyl-hydrazone (2), from the condensation reaction between usnic acid and isoniazid in an ethanol solution under reflux, giving an overall yield of 95%, were evaluated. Both compounds were evaluated and compared with isoniazid according to its antiMycobacterium tuberculosis activity based on the tetrazolium microplate assay (TEMA). Compound 1 had MIC (minimal inhibitory concentration) value of 16.0 μg/mL in each test of H37Rv (susceptible type), TB DM 97 (resistant wild type) and MDR DM 1098 (multi drug resistances type) strains. In similar tests, compound 2 MIC values were 2.0, 64.0 and 64.0 μg/mL respectively.
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U2 - 10.15446/rev.colomb.quim.v46n3.61980
DO - 10.15446/rev.colomb.quim.v46n3.61980
M3 - Article
SN - 0120-2804
SP - 17
EP - 21
JO - Revista Colombiana de Quimica
JF - Revista Colombiana de Quimica
ER -
