Tetradentate metal complexes derived from cephalexin and 2,6-diacetylpyridine bis(hydrazone): Synthesis, characterization and antibacterial activity

J. R. Anacona, Victor Rangel, Marcos Loroño, Juan Camus

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

25 Citas (Scopus)

Resumen

Abstract Metal(II) coordination compounds of a hydrazone ligand (HL) derived from the condensation of cephalexin antibiotic with 2,6-diacetylpyridine bis(hydrazone) were synthesized. The hydrazone ligand and mononuclear [ML(H2O)2][PF6] (M(II) = Mn, Co, Ni, Zn) complexes were characterized by several techniques, including elemental and thermal analysis, molar conductance and magnetic susceptibility measurements, electronic, FT-IR, EPR and 1H NMR spectral studies. The cephalexin 2,6-diacetylpyridine bis(hydrazone) ligand HL behaves as a monoanionic tetradentate NNNO chelating agent. The biological applications of complexes have been studied on two bacteria strains (Escherichia coli and Staphylococcus aureus) by agar diffusion disc method.

Idioma originalInglés
Número de artículo13605
Páginas (desde-hasta)23-29
Número de páginas7
PublicaciónSpectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
Volumen149
DOI
EstadoPublicada - 5 oct. 2015
Publicado de forma externa

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Publisher Copyright:
© 2015 Elsevier B.V. All rights reserved.

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