TY - JOUR
T1 - Tetradentate metal complexes derived from cephalexin and 2,6-diacetylpyridine bis(hydrazone)
T2 - Synthesis, characterization and antibacterial activity
AU - Anacona, J. R.
AU - Rangel, Victor
AU - Loroño, Marcos
AU - Camus, Juan
N1 - Publisher Copyright:
© 2015 Elsevier B.V. All rights reserved.
PY - 2015/10/5
Y1 - 2015/10/5
N2 - Abstract Metal(II) coordination compounds of a hydrazone ligand (HL) derived from the condensation of cephalexin antibiotic with 2,6-diacetylpyridine bis(hydrazone) were synthesized. The hydrazone ligand and mononuclear [ML(H2O)2][PF6] (M(II) = Mn, Co, Ni, Zn) complexes were characterized by several techniques, including elemental and thermal analysis, molar conductance and magnetic susceptibility measurements, electronic, FT-IR, EPR and 1H NMR spectral studies. The cephalexin 2,6-diacetylpyridine bis(hydrazone) ligand HL behaves as a monoanionic tetradentate NNNO chelating agent. The biological applications of complexes have been studied on two bacteria strains (Escherichia coli and Staphylococcus aureus) by agar diffusion disc method.
AB - Abstract Metal(II) coordination compounds of a hydrazone ligand (HL) derived from the condensation of cephalexin antibiotic with 2,6-diacetylpyridine bis(hydrazone) were synthesized. The hydrazone ligand and mononuclear [ML(H2O)2][PF6] (M(II) = Mn, Co, Ni, Zn) complexes were characterized by several techniques, including elemental and thermal analysis, molar conductance and magnetic susceptibility measurements, electronic, FT-IR, EPR and 1H NMR spectral studies. The cephalexin 2,6-diacetylpyridine bis(hydrazone) ligand HL behaves as a monoanionic tetradentate NNNO chelating agent. The biological applications of complexes have been studied on two bacteria strains (Escherichia coli and Staphylococcus aureus) by agar diffusion disc method.
KW - Antibacterial activity
KW - Cephalexin 2,6-diacetylpyridine bis(hydrazone) ligand
KW - Hydrazone metal complexes
KW - Synthesis hydrazone containing cephalexin
UR - http://www.scopus.com/inward/record.url?scp=84929465090&partnerID=8YFLogxK
U2 - 10.1016/j.saa.2015.04.054
DO - 10.1016/j.saa.2015.04.054
M3 - Artículo
C2 - 25942081
AN - SCOPUS:84929465090
SN - 1386-1425
VL - 149
SP - 23
EP - 29
JO - Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
JF - Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
M1 - 13605
ER -