TY - JOUR
T1 - The Int7G24A variant of transforming growth factor-beta receptor type I is a risk factor for colorectal cancer in the male Spanish population
T2 - A case-control study
AU - Castillejo, Adela
AU - Mata-Balaguer, Trinidad
AU - Guarinos, Carla
AU - Castillejo, María Isabel
AU - Martínez-Cantó, Ana
AU - Barberá, Víctor Manuel
AU - Montenegro, Paola
AU - Ochoa, Enrique
AU - Lázaro, Rafael
AU - Guillén-Ponce, Carmen
AU - Carrato, Alfredo
AU - Soto, José Luís
N1 - Funding Information:
This action has been performed within the cooperation framework established by the Transversal Cancer Action approved by the Council of Ministers on October 11th 2007 in accordance with the agreement between The Carlos III Health Institute (ISCIII), which is an autonomous entity currently belonging to the Ministry of Science and Innovation, and the Biomedical Research Foundation from the Hospital of Elche. Research supported in part by grants from the Generalitat Valenciana in Spain (AP106/06) and the Biomedical Research Foundation from the Hospital of Elche, Spain (FIBElx-02/2007). T.M-B is recipient of a fellowship from the Spanish Society of Medical Oncology (SEOM).
PY - 2009/11/20
Y1 - 2009/11/20
N2 - Background: The Int7G24A variant of transforming growth factor-beta receptor type I (TGFBR1) has been shown to increase the risk for kidney, ovarian, bladder, lung and breast cancers. Its role in colorectal cancer (CRC) has not been established. The aims of this study were to assess the association of TGFBR1*Int7G24A variant with CRC occurrence, patient age, gender, tumour location and stage. Methods: We performed a case-control study with 504 cases of sporadic CRC; and 504 non-cancerous age, gender and ethnically matched controls. Genotyping analysis was performed using allelic discrimination assay by real time PCR. Results: The Int7G24A variant was associated with increased CRC incidence in an additive model of inheritance (P for trend = 0.005). No significant differences were found between Int7G24A genotypes and tumour location or stage. Interestingly, the association of the Int7G24A variant with CRC risk was significant in men (odds ratio 4.10 with 95% confidence intervals 1.41-11.85 for homozygous individuals; P for trend = 0.00023), but not in women. We also observed an increase in susceptibility to CRC for individuals aged less than 70 years. Conclusion: Our data suggest that the Int7G24A variant represents a risk factor for CRC in the male Spanish population.
AB - Background: The Int7G24A variant of transforming growth factor-beta receptor type I (TGFBR1) has been shown to increase the risk for kidney, ovarian, bladder, lung and breast cancers. Its role in colorectal cancer (CRC) has not been established. The aims of this study were to assess the association of TGFBR1*Int7G24A variant with CRC occurrence, patient age, gender, tumour location and stage. Methods: We performed a case-control study with 504 cases of sporadic CRC; and 504 non-cancerous age, gender and ethnically matched controls. Genotyping analysis was performed using allelic discrimination assay by real time PCR. Results: The Int7G24A variant was associated with increased CRC incidence in an additive model of inheritance (P for trend = 0.005). No significant differences were found between Int7G24A genotypes and tumour location or stage. Interestingly, the association of the Int7G24A variant with CRC risk was significant in men (odds ratio 4.10 with 95% confidence intervals 1.41-11.85 for homozygous individuals; P for trend = 0.00023), but not in women. We also observed an increase in susceptibility to CRC for individuals aged less than 70 years. Conclusion: Our data suggest that the Int7G24A variant represents a risk factor for CRC in the male Spanish population.
UR - http://www.scopus.com/inward/record.url?scp=71549140359&partnerID=8YFLogxK
U2 - 10.1186/1471-2407-9-406
DO - 10.1186/1471-2407-9-406
M3 - Artículo
C2 - 19930569
AN - SCOPUS:71549140359
SN - 1471-2407
VL - 9
JO - BMC Cancer
JF - BMC Cancer
M1 - 406
ER -